Vidal-Gadea Lab Research Impact Dashboard

Professor Andrés G. Vidal-Gadea, Ph.D.
School of Biological Sciences, Illinois State University
Last updated: December 2025
2015
Started Lab
Assistant Professor
2020
Promoted
Associate Professor
2025
Promoted
Full Professor
30
Peer-Reviewed Publications
962
Total Citations
15
h-index
$1.47M
Total Research Funding (PI)

Research Philosophy

Our lab investigates how animals interact with the physical world. We focus on specific physical variables that living systems must detect, respond to, and survive: mechanical forces, magnetic fields, gravity, and temperature. We ask how animals sense these parameters, how they generate and withstand forces, and what happens when these systems fail in disease.

Understanding these interactions requires developing new approaches to measure and manipulate them. Our lab builds behavioral assays, measurement systems, and molecular tools that enable quantitative analysis of organism-environment interactions. This approach bridges basic discovery with translational applications to neuromuscular disease and extreme environments.

1
Physical Interactions
Which physical parameters matter to living systems?
Mechanical forces, magnetic fields, gravity, temperature. The subset of physics that organisms evolved to detect and respond to.
2
Mechanisms & Pathology
How do these interactions work, and what happens when they fail?
Sensory transduction (magnetosensation, mechanoreception, thermosensation). Force generation (muscle contraction, locomotion). Disease states (DMD, calcium dysregulation).
3
Tools & Methods
Developing approaches to measure and manipulate
Novel behavioral assays, measurement systems, molecular reporters, mathematical models. Open access tools and protocols for research and education.

Research Tools & Innovation

Behavioral Assays
Swim/crawl transition assay (PNAS 2011), burrowing assay for neuromuscular integrity (2015), magnetic orientation tracking systems. Custom measurement approaches for natural behaviors.
Instrumentation
Custom magnetic coil systems (multiple configurations for field manipulation), magnetic pulse generators, WormBot adaptation for high throughput analysis, affordable worm tracker (open access design).
Human Muscle Physiology System (2025)
Integrated system for force measurement, calcium imaging, and temperature control in 3D human skeletal muscle constructs. Synchronized electrical stimulation with multi-modal data acquisition.
Molecular Tools
RGBCaMP multi-compartment calcium reporter (simultaneous cytoplasm, mitochondria, SR imaging), thermosensitive fluorescent reporters, complete dystrophin knockout strains (VG02/VG03), CRISPR generated dystrophic human myoblasts.
Method Dissemination
Published protocols and book chapters, open access designs and code, YouTube video library (71 videos, 36K views), comprehensive training materials for 216+ students.

Recent Awards and Recognition

2025
Outstanding University Researcher, Illinois State University
2024
Outstanding College Researcher, Illinois State University
2021
Million Dollar Club, Illinois State University
2020
Researchers to Know, Illinois Science & Technology Coalition
2019
Research Initiative Award, Illinois State University
2018
Outstanding STEM Professional Award, McLean County Chamber of Commerce
2018
Faculty Mentor Award, Louis Stokes Alliance for Minority Participation

Recent Publications (2025)

Activity-dependent remodeling of muscle architecture during distinct locomotor behaviors in C. elegans
Fazyl A, Anbu A, Kollbaum S, Vidal-Gadea AG
Biology Open (2025) - Accepted
Fibrillin-Related Proteins Control Calcium Homeostasis in Dystrophic Muscle Across Species
Marchiafava D, Vidal-Gadea AG
microPublications Biology (2025)
Independent Validation of Transgenerational Inheritance of Learned Pathogen Avoidance in C. elegans
Akinosho A, Alexander J, Floyd K, Vidal-Gadea AG
eLife (2025)

High-Impact Publications

Physical exertion exacerbates decline in the musculature of an animal model of Duchenne muscular dystrophy
Hughes K, Rodriguez A, Flatt K, et al., Vidal-Gadea AG
PNAS (2019) - Featured in Medical Xpress
Magnetosensitive neurons mediate geomagnetic orientation in C. elegans
Vidal-Gadea AG, Ward K, Beron C, et al., Pierce-Shimomura JT
eLife (2015) - Featured in Nature Reviews, NPR, Scientific American
C. elegans selects distinct crawling and swimming gaits via dopamine and serotonin
Vidal-Gadea AG, Topper S, Young L, et al., Pierce-Shimomura JT
PNAS (2011) - Featured in Scientific American, CBS News
Coding characteristics of spiking local interneurons during imposed limb movements in the locust
Vidal-Gadea AG, Jing XJ, Simpson D, et al., Newland PL
Journal of Neurophysiology (2010) - Wiener kernel mathematical modeling

Active Research Grant

NIH R15 (NIAMS)
2022-2025 | $375,393 | Genetic repair of muscular degeneration associated with Duchenne muscular dystrophy

Research Programs

Duchenne Muscular Dystrophy
Investigating pathophysiology using C. elegans and human myocyte models. Developed first cross-tissue DMD model and complete dystrophin knockout strains. Building force and calcium measurement systems for human muscle constructs.
Mechanotransduction
Studying how organisms detect and respond to mechanical forces. PEZO-1 mechanoreceptors in muscle function, locomotion, and feeding. Proprioceptive systems in locusts using Wiener kernel analysis.
Magnetic Field Bionavigation
Pioneering work on nematode magnetosensation. Identified magnetosensitive neurons and investigating molecular mechanisms. Custom magnetic coil systems and pulse generators for mechanism discovery.
Neuromuscular Systems
Motor control, muscle plasticity, and neuromuscular communication. Novel behavioral assays for neuromuscular integrity. Gait selection mechanisms via neuromodulators.
Astrobiology Research
Investigating multigenerational effects of simulated Martian conditions (reduced gravity and hypomagnetic fields) on C. elegans. Custom systems to manipulate physical parameters of extraterrestrial environments.
Crustacean Neurogenetics
Developing first genetic tools for decapod neuroscience using marbled crayfish. Collaboration exploring neuromodulation and neural network dynamics.

Citation Growth

Student Mentoring Excellence

Transformative Educational Impact (2015-2025)

216
Total Students Mentored
572+
Total Student Outputs
200+
Conference Presentations
90%+
STEM Career Placement

Lab performance dramatically exceeds national averages: 216 students mentored vs. 35-50 national average. Students learn quantitative approaches to biological questions, develop technical skills across multiple systems, and gain research independence.

View Detailed Student Mentoring Dashboard

Media Coverage and Science Communication

Major Media Features
NPR, NBC News, Scientific American, Nature Reviews, The Scientist, Medical Press, RAI (Italy), El País (Uruguay), Pantagraph, 25News
Digital Science Communication
71+ research videos on YouTube with 36,000+ views, comprehensive web portfolio, interactive research dashboards, science outreach coloring book
Public Engagement
Regular K-12 science education programming, podcast appearances, community science events, educational resource development